Clarithromed

Clarithromed may be available in the countries listed below.

Ingredient matches for Clarithromed

Clarithromycin

Clarithromycin is reported as an ingredient of Clarithromed in the following countries:

• Belgium

International Drug Name Search

Neggram

Generic Name: nalidixic acid (Oral route)

nal-i-DIX-ik AS-id

Commonly used brand name(s):

In the U.S.

• Neggram

Available Dosage Forms:

• Tablet


• Suspension

Therapeutic Class: Antibiotic

Chemical Class: Non-Fluorinated Quinolone

Uses For Neggram

Nalidixic acid is used to treat infections of the urinary tract. This medicine belongs to the group of medicines known as quinolone antibiotics. It works by killing the bacteria and preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using Neggram

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nalidixic acid in infants younger than 3 months of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nalidixic acid in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving nalidixic acid.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Ajmaline


• Disopyramide


• Pirmenol


• Prajmaline


• Procainamide


• Quinidine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Melphalan


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bradycardia (slow heartbeat), history of or


• Diarrhea or


• Heart attack, recent or


• Heart rhythm problems (e.g., QT prolongation), history of or


• Hypokalemia (low potassium in the blood) or


• Liver disease—Use with caution. May make these conditions worse.

• Cerebral arteriosclerosis (hardening of the arteries in the brain) or


• Glucose-6-phosphate dehydrogenase (G6PD) deficiency—May cause side effects to become worse.

• Convulsive disorders (seizures, epilepsy), history of or


• Porphyria (enzyme problem)—Should not be used in patients with these conditions.

• Kidney disease—Effects may be increased because of slower removal of the medicine from the body.

Proper Use of Neggram

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine may be taken with or without food. Drink plenty of fluids every day while you are using nalidixic acid.

If you or your child are taking aluminum, calcium, or magnesium-containing antacids, didanosine oral liquid (e.g., Videx®), iron supplements, multivitamins, zinc, or sucralfate (e.g., Carafate®), do not take them at the same time that you take this medicine. It is best to take these medicines at least 2 hours before or 2 hours after the nalidixic acid.

To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if you or your child begin to feel better after a few days. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (tablets):
  
  • For urinary tract infection:
    
    • Adults, teenagers, and children 12 years of age and older—At first, 1000 milligrams (mg) four times a day. Your doctor may adjust your dose if needed.
    
    
    • Children 3 months to 12 years of age—Dose is based on body weight and must be determined by your doctor. At first, the dose is usually 55 milligrams (mg) per kilogram (kg) of body weight per day, divided and given in four doses. Your doctor may adjust your dose if needed.
    
    
    • Infants younger than 3 months of age—Use is not recommended.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Neggram

If you will be taking this medicine for more than 2 weeks, it is very important that your doctor check you or your child's progress at regular visits. Blood tests may be needed to check for unwanted effects.

If your or your child's symptoms do not improve within 2 days, or if they become worse, check with your doctor.

Do not breastfeed while you are using this medicine.

Do not use melphalan (e.g., Alkeran®) or other similar cancer medicines while you are taking this medicine. Using these medicines together may increase your risk for more serious side effects.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you or your child have a rash; itching; hives; hoarseness; shortness of breath; trouble with breathing; trouble with swallowing; or any swelling of your hands, face, or mouth after you take this medicine.

Nalidixic acid may cause diarrhea, and in some cases it can be severe. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Tell your doctor right away if you or your child start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy.

This medicine may rarely cause inflammation or tearing of a tendon (the cord that attaches muscles to bones). The risk of having tendon problems may be increased if you are over 60 years of age or if you are also using steroid medicines (e.g., dexamethasone, prednisolone, prednisone, Medrol®). If you or your child get sudden pain in a tendon after exercise (e.g., in the ankle, back of the knee or leg, shoulder, elbow, or wrist), stop taking nalidixic acid and check with your doctor right away. Rest and do not exercise until the doctor has made sure that you have not injured or torn the tendon.

This medicine may cause blurred vision or other vision problems. It may also cause some people to become dizzy, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert or able to see well. If these reactions are especially bothersome, check with your doctor.

This medicine may increase the central nervous system (CNS) stimulant effects of caffeine-containing foods or beverages, such as chocolate, cocoa, tea, coffee, and cola drinks. Avoid eating or drinking large amounts of these foods or beverages while using this medicine. If you have questions about this, check with your doctor.

Nalidixic acid may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin using this medicine:

• Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.


• Wear protective clothing, including a hat. Also, wear sunglasses.


• Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your doctor.


• Apply a sun block lipstick that has an SPF of at least 15 to protect your lips.


• Do not use a sunlamp, tanning bed, or tanning booth.

If you or your child have a severe reaction from the sun, stop using this medicine and check with your doctor right away.

This medicine may cause false test results with some urine glucose (sugar) tests. If you or your child are diabetic, check with your doctor before changing your diet or the dose of your diabetes medicine while you are using nalidixic acid.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Neggram Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Skin rash

Less common

• Blurred or decreased vision


• change in color vision


• confusion


• double vision


• halos around lights


• lightheadedness


• overbright appearance of lights


• restlessness


• tremor

Rare

• Abdominal or stomach cramps or pain (severe)


• blistering, peeling, or loosening of the skin and mucous membranes


• bulging of fontanel (soft spot) on top of the head of an infant


• burning or tingling skin sensation


• changes in facial skin color


• chills


• convulsions (seizures)


• dark or amber urine


• diarrhea, watery and severe, which may also be bloody


• fever


• general feeling of discomfort or illness


• hallucinations (seeing, hearing, or feeling things that are not there)


• headache (severe)


• hives


• hoarseness


• increased frequency of breathing


• itching


• joint pain, stiffness, or swelling


• mood or other mental changes


• nausea or vomiting


• pale skin


• pale stools


• red skin lesions, often with a purple center


• shortness of breath


• sore throat


• sudden trouble in swallowing or breathing


• swelling of the face, mouth, hands, or feet


• unusual bleeding or bruising


• unusual tiredness or weakness


• visual changes


• yellow eyes or skin

Incidence not known

• Black, tarry stools


• bone pain


• burning, numbness, tingling, or painful sensations


• chest pain


• cough


• difficulty with swallowing


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• lower back or side pain


• painful or difficult urination


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• redness of the skin


• sores, ulcers, or white spots on the lips or in the mouth


• swollen glands


• tightness in the chest


• unsteadiness or awkwardness


• weakness in the arms, hands, legs, or feet


• welts


• wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Aggressive and violent behavior


• change in the ability to see colors, especially blue or yellow


• drowsiness


• headache


• loss of appetite


• rapid, deep breathing


• trouble with sleeping


• unable to sleep


• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Diarrhea


• dizziness


• feeling of constant movement of self or surroundings


• stomach pain


• weakness

Less common

• Increased sensitivity of the skin to sunlight

Incidence not known

• Difficulty with moving


• muscle pain or stiffness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Neggram side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Neggram resources

• Neggram Side Effects (in more detail)
• Neggram Use in Pregnancy & Breastfeeding
• Drug Images
• Neggram Drug Interactions
• Neggram Support Group
• 0 Reviews for Neggram - Add your own review/rating

• NegGram Prescribing Information (FDA)


• NegGram MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Neggram with other medications

• Bladder Infection
• Prevention of Bladder infection

Frusehexal

Frusehexal may be available in the countries listed below.

Ingredient matches for Frusehexal

Furosemide

Furosemide is reported as an ingredient of Frusehexal in the following countries:

• Australia

International Drug Name Search

Farmaciclin

Farmaciclin may be available in the countries listed below.

Ingredient matches for Farmaciclin

Vancomycin

Vancomycin hydrochloride (a derivative of Vancomycin) is reported as an ingredient of Farmaciclin in the following countries:

• Italy

International Drug Name Search

Bidex 400

Generic Name: guaifenesin (Oral route)

gwye-FEN-e-sin

Commonly used brand name(s)

In the U.S.

• Allfen


• Altarussin


• Amibid LA


• Antitussin


• Bidex 400


• Diabetic Siltussin DAS-Na


• Diabetic Tussin EX


• Drituss G


• Guaifenex G


• Guaifenex LA


• Mucinex


• Robitussin

In Canada

• Benylin-E


• Benylin E Extra Strength Chest Congestion


• Broncho-Grippex Expectorant


• Robitussin Extra Strength

Available Dosage Forms:

• Tablet, Extended Release


• Solution


• Capsule, Extended Release


• Packet


• Liquid


• Tablet


• Capsule


• Elixir


• Syrup

Therapeutic Class: Expectorant

Uses For Bidex 400

Guaifenesin is used to help clear mucus or phlegm (pronounced flem) from the chest when you have congestion from a cold or flu. It works by thinning the mucus or phlegm in the lungs.

This medicine is available both over-the-counter (OTC) and with your doctor's prescription.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

Before Using Bidex 400

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of guaifenesin in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults. However, check with your doctor before using this medicine in children who have a chronic cough, such as occurs with asthma, or who have an unusually large amount of mucus or phlegm with the cough. Children with these conditions may need a different kind of medicine. Also, guaifenesin should not be given to children and infants younger than 2 years of age unless you are directed to do so by your doctor.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of guaifenesin in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of guaifenesin

This section provides information on the proper use of a number of products that contain guaifenesin. It may not be specific to Bidex 400. Please read with care.

Drinking plenty of water while taking guaifenesin may help loosen mucus or phlegm in the lungs.

For patients taking the extended-release capsule form of this medicine:

• Swallow the capsule whole, or open the capsule and sprinkle the contents on soft food such as applesauce, jelly, or pudding and swallow without crushing or chewing.

For patients taking the extended-release tablet form of this medicine:

• If the tablet has a groove in it, you may carefully break it into two pieces along the groove. Then swallow the pieces whole, without crushing or chewing them.


• If the tablet does not have a groove, it must be swallowed whole. Do not break, crush, or chew it before swallowing.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For regular (short-acting) oral dosage forms (capsules, oral solution, syrup, or tablets):
  
  • For cough:
    
    • Adults—200 to 400 milligrams (mg) every four hours.
    
    
    • Children 6 to 12 years of age—100 to 200 mg every four hours.
    
    
    • Children 4 to 6 years of age—50 to 100 mg every four hours.
    
    
    • Children and infants up to 4 years of age—Use is not recommended .
    
    
  
  


• For long-acting oral dosage forms (extended-release capsules or tablets):
  
  • For cough:
    
    • Adults—600 to 1200 mg every twelve hours.
    
    
    • Children 6 to 12 years of age—600 mg every twelve hours.
    
    
    • Children 4 to 6 years of age—300 mg every twelve hours.
    
    
    • Children and infants up to 4 years of age—Use is not recommended .
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Bidex 400

If your cough has not improved after 7 days or if you have a fever, skin rash, continuing headache, or sore throat with the cough, check with your doctor. These signs may mean that you have other medical problems.

Bidex 400 Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

• Diarrhea


• dizziness


• headache


• hives


• nausea or vomiting


• skin rash


• stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Bidex 400 side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Bidex 400 resources

• Bidex 400 Side Effects (in more detail)
• Bidex 400 Use in Pregnancy & Breastfeeding
• Bidex 400 Support Group
• 0 Reviews for Bidex 400 - Add your own review/rating

Compare Bidex 400 with other medications

• Bronchitis
• Cough

Nelfinavir Powder

Pronunciation: nel-FIN-a-vir
Generic Name: Nelfinavir
Brand Name: Viracept

Nelfinavir Powder is used for:

Treating HIV infection in combination with other medicines.

Nelfinavir Powder is an HIV protease inhibitor. It works by blocking a substance that is needed for the HIV virus to multiply.

Do NOT use Nelfinavir Powder if:

• you are allergic to any ingredient in Nelfinavir Powder


• you have moderate to severe liver problems


• you are taking alfuzosin, amiodarone, astemizole, carbamazepine, certain benzodiazepines (eg, midazolam, triazolam), cisapride, an ergot derivative (eg, ergotamine, dihydroergotamine), certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), phenobarbital, pimozide, omeprazole, quinidine, rifampin, salmeterol, St. John's wort, or terfenadine


• you are taking sildenafil for pulmonary arterial hypertension (PAH)


• you have taken eletriptan within the past 72 hours

Contact your doctor or health care provider right away if any of these apply to you.

Before using Nelfinavir Powder:

Some medical conditions may interact with Nelfinavir Powder. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have liver or kidney problems, diabetes, high blood sugar, or hemophilia


• if you have phenylketonuria

Some MEDICINES MAY INTERACT with Nelfinavir Powder. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Carbamazepine, omeprazole, phenobarbital, rifampin, or St. John's wort because they may decrease Nelfinavir Powder's effectiveness


• Alfuzosin, amiodarone, astemizole, certain benzodiazepines (eg, midazolam, triazolam), cisapride, eletriptan, ergot derivatives (eg, dihydroergotamine, ergotamine), certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), pimozide, quinidine, salmeterol, sildenafil (when used for PAH), or terfenadine because the risk of their side effects may be increased by Nelfinavir Powder


• Many prescription and nonprescription medicines (eg, used for infections, inflammation, aches and pains, allergies, asthma, birth control, blood thinning, cancer, enlarged prostate, erectile dysfunction, gout, HIV, heart problems, high blood pressure, high cholesterol, heartburn or ulcers, immune system suppression, irregular heartbeat, mental or mood problems, migraine headaches, PAH, seizures, trouble sleeping), multivitamin products, and herbal or dietary supplements (eg, coenzyme Q10, garlic, ginkgo, ginseng, herbal teas, St. John's wort) may interact with Nelfinavir Powder, increasing the risk of side effects or decreasing effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nelfinavir Powder may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Nelfinavir Powder:

Use Nelfinavir Powder as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Nelfinavir Powder. Talk to your pharmacist if you have questions about this information.


• Take Nelfinavir Powder by mouth with a meal.


• Use the scoop provided with Nelfinavir Powder to measure your dose.


• Nelfinavir Powder may be mixed with water, milk, formula, soy formula, soy milk, dietary supplements, or dairy foods (eg, pudding, ice cream). Do not mix Nelfinavir Powder in its original container. Do not mix it with any acidic food (eg, orange or grapefruit juice, apple juice, applesauce). Do not heat the mixed dose once it has been prepared.


• Take Nelfinavir Powder immediately after mixing. It may also be stored in the refrigerator for up to 6 hours after mixing.


• Once the medicine is mixed, consume the entire mixture to get the full dose. Rinse the glass or container with water and swallow the rinse to be sure that the entire dose is taken.


• If you are taking didanosine, take it at least 1 hour before or more than 2 hours after Nelfinavir Powder.


• Take Nelfinavir Powder on a regular schedule to get the most benefit from it. Taking it at the same time each day will help you remember to take it.


• Continue to take Nelfinavir Powder even if you feel well. Do not miss any doses.


• If you miss a dose of Nelfinavir Powder, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss several doses of Nelfinavir Powder, check with your doctor.

Ask your health care provider any questions you may have about how to use Nelfinavir Powder.

Important safety information:

• Keep a list of all the medicines that you take. Make a new list each time a medicine is added or stopped. Find out about medicines that should not be taken while you are taking Nelfinavir Powder. Be sure that each of your health care providers knows all the medicines that you are taking.


• Do NOT take more than the recommended dose, change the dose, or stop taking Nelfinavir Powder without checking with your doctor.


• Nelfinavir Powder is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.


• When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Nelfinavir Powder, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.


• Nelfinavir Powder does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.


• Hormonal birth control (eg, birth control pills) may not work as well while you are using Nelfinavir Powder. To prevent pregnancy, use an extra form of birth control (eg, condoms).


• Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Nelfinavir Powder. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.


• Nelfinavir Powder may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start Nelfinavir Powder.


• Some of these products contain phenylalanine. If you must have a diet that is low in phenylalanine, ask your pharmacist if it is in your product.


• Nelfinavir Powder may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.


• Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Lab tests, including CD4 counts, may be performed while you use Nelfinavir Powder. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Nelfinavir Powder with caution in CHILDREN; they may be more sensitive to it effects, especially loss of appetite and low white blood cell levels.


• Nelfinavir Powder should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Nelfinavir Powder while you are pregnant. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Nelfinavir Powder to the baby.

Possible side effects of Nelfinavir Powder:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; gas; loss of appetite; nausea; stomach pain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever, chills, or sore throat; mental or mood changes; suicidal thoughts or actions; symptoms of high blood sugar (eg, confusion; flushed face; fruit-like breath odor; increased thirst, hunger, or urination; unusual drowsiness); unusual bleeding or bruising.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Nelfinavir side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Nelfinavir Powder:

Store Nelfinavir Powder at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in its original container. Store away from heat, light, and moisture. Do not store in the bathroom. Keep Nelfinavir Powder out of the reach of children and away from pets.

General information:

• If you have any questions about Nelfinavir Powder, please talk with your doctor, pharmacist, or other health care provider.


• Nelfinavir Powder is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Nelfinavir Powder. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Nelfinavir resources

• Nelfinavir Side Effects (in more detail)
• Nelfinavir Use in Pregnancy & Breastfeeding
• Nelfinavir Drug Interactions
• Nelfinavir Support Group
• 0 Reviews for Nelfinavir - Add your own review/rating

Compare Nelfinavir with other medications

• HIV Infection
• Nonoccupational Exposure
• Occupational Exposure

Ergokod

Ergokod may be available in the countries listed below.

Ingredient matches for Ergokod

Dihydroergotoxine

Dihydroergotoxine is reported as an ingredient of Ergokod in the following countries:

• Tunisia

International Drug Name Search

Naphcon Forte

Generic Name: naphazoline ophthalmic (na FAZ oh leen)

Brand Names: AK-Con, Albalon, Allerest Eye Drops, Clear Eyes, Degest 2, Estivin II, Nafazair, Naphcon, Naphcon Forte, VasoClear, Vasocon

What is Naphcon Forte (naphazoline ophthalmic)?

Naphazoline ophthalmic causes constriction of blood vessels in the eyes. It also decreases itching and irritation of the eyes.

Naphazoline ophthalmic is used to relieve redness, burning, irritation, and dryness of the eye caused by wind, sun, and other minor irritants.

Naphazoline ophthalmic may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Naphcon Forte (naphazoline ophthalmic)?

Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye.

If you wear contact lenses, remove them before applying naphazoline ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Naphazoline ophthalmic may contain a preservative (benzalkonium chloride), which may cause discoloration of contact lenses.

Do not use naphazoline ophthalmic more often or continuously for longer than 48 to 72 hours without consulting a doctor. Chronic use of this medication may damage the blood vessels (veins and arteries) in the eyes. Consult a doctor if your symptoms do not improve or appear to worsen.

What should I discuss with my healthcare provider before using Naphcon Forte (naphazoline ophthalmic)?

Do not use naphazoline ophthalmic if you have glaucoma, except under the supervision of your doctor.

Before using this medication, tell your doctor if you

• 
  

  have any type of heart condition, including high blood pressure;

  
  


• 
  

  take any medicines to treat a heart condition;

  
  


• 
  

  have asthma;

  
  


• 
  

  have diabetes; or

  
  


• 
  

  have thyroid problems.

  
  

You may not be able to use naphazoline ophthalmic, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

If you wear contact lenses, remove them before applying naphazoline ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Naphazoline ophthalmic may contain a preservative (benzalkonium chloride), which may cause discoloration of contact lenses.

Naphazoline ophthalmic is in the FDA pregnancy category C. This means that it is not known whether naphazoline ophthalmic will be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether naphazoline passes into breast milk. Do not use naphazoline ophthalmic without first talking to your doctor if you are breast-feeding a baby.

How should I use Naphcon Forte (naphazoline ophthalmic)?

Use naphazoline eye drops exactly as directed by your doctor, or follow the directions that accompany the package. If you do not understand these instructions, ask your doctor, pharmacist, or nurse to explain them to you.

Wash your hands before and after using the eye drops.

To apply the eye drops:

If you wear contact lenses, remove them before applying naphazoline ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Naphazoline ophthalmic may contain a preservative (benzalkonium chloride), which may cause discoloration of contact lenses.

• 
  

  Tilt the head back slightly and pull down on the lower eyelid. Position the dropper above the eye. Look up and away from the dropper. Squeeze out a drop and close the eye. Apply gentle pressure to the inside corner of the eye (near the nose) for about 1 minute to prevent the liquid from draining down your tear duct. Repeat the process in the other eye if needed..

  
  

Do not use naphazoline ophthalmic more often or continuously for longer than 48 to 72 hours without consulting a doctor. Chronic use of this medication may damage the blood vessels (veins and arteries) in the eyes. Consult a doctor if your symptoms do not improve or appear to worsen. Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye. Do not use any eye drop that is discolored or has particles in it. Store naphazoline ophthalmic at room temperature away from moisture and heat. Keep the bottle properly capped.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?

An overdose of this medication is unlikely to be harmful. If you do suspect an overdose, or if the drops have been ingested (taken by mouth), contact an emergency room or poison control center for advice.

What should I avoid while using Naphcon Forte (naphazoline ophthalmic)?

Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye.

If you wear contact lenses, remove them before applying naphazoline ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Naphazoline ophthalmic may contain a preservative (benzalkonium chloride), which may cause discoloration of contact lenses.

Do not use naphazoline ophthalmic more often or continuously for longer than 48 to 72 hours without consulting a doctor. Chronic use of this medication may damage the blood vessels (veins and arteries) in the eyes. Consult a doctor if your symptoms do not improve or appear to worsen.

Naphcon Forte (naphazoline ophthalmic) side effects

If you experience any of the following serious side effects, stop using naphazoline ophthalmic and seek emergency medical attention or contact your doctor immediately:

• 
  

  an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, face, or tongue; or hives);

  
  


• 
  

  an irregular or fast heart rate; or

  
  


• 
  

  high blood pressure (severe headache, blurred vision, or flushed skin).

  
  

Other, less serious side effects may be more likely to occur. Continue to use naphazoline ophthalmic and talk to your doctor if you experience

• 
  

  burning, stinging, pain, or increased redness of the eye;

  
  


• 
  

  tearing or blurred vision;

  
  


• 
  

  headache;

  
  


• 
  

  tremor;

  
  


• 
  

  nausea;

  
  


• 
  

  sweating;

  
  


• 
  

  nervousness;

  
  


• 
  

  dizziness; or

  
  


• 
  

  drowsiness.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Naphcon Forte (naphazoline ophthalmic)?

Do not use other eye medications during treatment with naphazoline ophthalmic except under the direction of your doctor.

Although drug interactions between naphazoline ophthalmic and drugs taken by mouth are not expected, they can occur. Before using this medication, tell your doctor if you are taking any of the following medicines:

• 
  

  a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil); or

  
  


• 
  

  a beta-blocker such as propranolol (Inderal), metoprolol (Lopressor, Toprol XL), or labetalol (Normodyne, Trandate).

  
  

You may not be able to use naphazoline ophthalmic, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with naphazoline ophthalmic. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

More Naphcon Forte resources

• Naphcon Forte Side Effects (in more detail)
• Naphcon Forte Use in Pregnancy & Breastfeeding
• Naphcon Forte Drug Interactions
• Naphcon Forte Support Group
• 0 Reviews for Naphcon Forte - Add your own review/rating

• Naphcon Forte Prescribing Information (FDA)


• AK-Con Advanced Consumer (Micromedex) - Includes Dosage Information


• Albalon Prescribing Information (FDA)


• Clear Eyes Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• Naphcon Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• Naphcon Prescribing Information (FDA)


• Vasocon Prescribing Information (FDA)

Compare Naphcon Forte with other medications

• Eye Dryness/Redness
• Eye Redness/Itching

Where can I get more information?

• Your pharmacist has additional information about naphazoline ophthalmic written for health professionals that you may read.

See also: Naphcon Forte side effects (in more detail)

fluticasone topical

Generic Name: fluticasone topical (floo TIK a sone TOP i kal)

Brand Names: Cutivate

What is fluticasone topical?

Fluticasone is a steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and swelling.

Fluticasone topical (for the skin) is used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis.

Fluticasone topical should not be used to treat rosacea, severe acne, or viral skin infections such as chickenpox or herpes.

Fluticasone topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about fluticasone topical?

Topical steroid medicine can be absorbed through the skin, which may cause steroid side effects throughout the body. Do not use fluticasone topical in larger amounts, or for longer than recommended by your doctor. Do not apply to your face, underarms, or groin area unless your doctor tells you to.

Do not cover treated skin areas with a bandage or other covering unless your doctor has told you to. If you are treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers. Covering the skin that is treated with fluticasone topical can increase the amount of medicine your skin absorbs, which may lead to unwanted side effects. Do not use this medication on a child without medical advice. Children are more likely to absorb large amounts of a topical steroid through the skin. Steroid absorption in children may cause unwanted side effects, or a delay in growth with long-term use. Do not use fluticasone topical for longer than 2 weeks. Talk with your doctor if your symptoms do not improve, or if you develop signs of a bacterial, fungal, or viral skin infection.

What should I discuss with my healthcare provider before using fluticasone topical?

You should not use this medication if you are allergic to fluticasone or formaldehyde.

To make sure you can safely use fluticasone topical, tell your doctor if you have any type of skin infection.

Also tell your doctor if you have diabetes. Steroid medicines may increase the glucose (sugar) levels in your blood or urine. You may also need to adjust the dose of your diabetes medications.

FDA pregnancy category C. It is not known whether fluticasone topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether fluticasone topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not use this medication on a child without medical advice. Children are more likely to absorb large amounts of a topical steroid through the skin. Steroid absorption in children may cause unwanted side effects, or a delay in growth with long-term use. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.

How should I use fluticasone topical?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Topical steroid medicine can be absorbed through the skin, which may cause steroid side effects throughout the body.

Wash your hands before and after using fluticasone topical, unless you are using the medication to treat the skin on your hands.

Apply a small amount to the affected area and rub it gently into the skin. Do not apply the medication over a large area of skin, or use it long-term on the face. Do not use fluticasone topical on broken or infected skin. Also avoid using this medication in open wounds.

If you are treating your scalp, part the hair and apply the medicine directly to the scalp, rubbing in gently. Avoid washing or rubbing the treated scalp area right away. Wait until the medicine has dried thoroughly.

Do not cover treated skin areas with a bandage or other covering unless your doctor has told you to. If you are treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers. Covering the skin that is treated with fluticasone topical can increase the amount of medicine your skin absorbs, which may lead to unwanted side effects. Do not use fluticasone topical for longer than 2 weeks without your doctor's advice. Talk with your doctor if your symptoms do not improve, or if you develop signs of a bacterial, fungal, or viral skin infection.

If you use this medication long-term, your blood may need to be tested. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using fluticasone topical. Store at room temperature away from moisture, heat, and light. Do not freeze. Keep the tube or bottle tightly closed when not in use.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

An overdose of fluticasone topical is not expected to produce life threatening symptoms. However, long term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using fluticasone topical?

Do not use fluticasone topical to treat any skin condition that has not been checked by your doctor.

Do not use this medication to treat skin conditions around your mouth, rectum, or genital areas. Do not apply to your face, underarms, or groin area unless your doctor tells you to.

Avoid getting this medication in your eyes. If this does happen, rinse with water.

Avoid using other steroid medications on the areas you treat with fluticasone topical unless you doctor tells you to.

Fluticasone topical side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when fluticasone topical is applied to the skin, side effects can occur if the medication is absorbed into your bloodstream.

Stop using this medicine and call your doctor at once if you have signs of absorbing fluticasone topical through your skin, such as:

• 
  

  blurred vision, or seeing halos around lights;

  
  


• 
  

  headache, back ache, weakness, confusion, mood changes;

  
  


• 
  

  sleep problems (insomnia);

  
  


• 
  

  weight gain, puffiness in your face;

  
  


• 
  

  muscle weakness, feeling tired; or

  
  


• 
  

  high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss).

  
  

Less serious side effects may include:

• 
  

  mild skin itching, burning, peeling, or dryness;

  
  


• 
  

  changes in color of treated skin;

  
  


• 
  

  thinning or softening of your skin;

  
  


• 
  

  skin rash or irritation around your mouth;

  
  


• 
  

  redness or crusting around your hair follicles;

  
  


• 
  

  blisters, pimples, or crusting of treated skin; or

  
  


• 
  

  stretch marks.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Fluticasone topical Dosing Information

Usual Adult Dose for Dermatologic Lesion:

Cream: Apply a thin film to affected area twice daily.

Ointment: Apply sparingly in a thin film twice daily.

Usual Adult Dose for Atopic Dermatitis:

Cream: Apply a thin film to affected area once or twice daily.

Ointment: Apply sparingly in a thin film twice daily.

Lotion: Apply sparingly in a thin film to affected area once daily.

Usual Pediatric Dose for Dermatologic Lesion:

3 months to 12 years:
Cream: Apply a thin film to affected area twice daily. Safety and efficacy of use > 4 weeks has not been established.

13 years or older:
Ointment: Apply sparingly in a thin film to affected area twice daily

Usual Pediatric Dose for Atopic Dermatitis:

3 months to 11 months:
Cream: Apply a thin film to affected area twice daily. Safety and efficacy of use more than 4 weeks has not been established.

1 year to 11 years:
Lotion: Apply sparingly in a thin film to affected area once daily.

13 years or older:
Ointment: Apply sparingly in a thin film to affected area twice daily

What other drugs will affect fluticasone topical?

It is not likely that other drugs you take orally or inject will have an effect on topically applied fluticasone topical. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More fluticasone topical resources

• Fluticasone topical Dosage
• Fluticasone topical Use in Pregnancy & Breastfeeding
• Fluticasone topical Drug Interactions
• Fluticasone topical Support Group
• 5 Reviews for Fluticasone - Add your own review/rating

• Cutivate Prescribing Information (FDA)


• Cutivate Advanced Consumer (Micromedex) - Includes Dosage Information


• Cutivate Cream MedFacts Consumer Leaflet (Wolters Kluwer)

Compare fluticasone topical with other medications

• Atopic Dermatitis
• Dermatologic Lesion
• Lichen Sclerosus

Where can I get more information?

• Your pharmacist can provide more information about fluticasone topical.

roflumilast

Generic Name: roflumilast (roe FLOO mi last)

Brand Names: Daliresp

What is roflumilast?

Roflumilast reduces inflammation in the lungs that leads to COPD (chronic obstructive pulmonary disease).

Roflumilast is used to prevent worsening of chronic obstructive pulmonary disease (COPD) in people with severe COPD and chronic bronchitis.

Roflumilast is not a bronchodilator. It will not treat a bronchospasm attack that has already begun.

Roflumilast may also be used for purposes not listed in this medication guide.

What is the most important information I should know about roflumilast?

You should not use roflumilast if you are allergic to it, or if you have moderate or severe liver disease.

There are many other drugs that can make roflumilast less effective and should not be used at the same time. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Before you take roflumilast, tell your doctor if you have liver disease or a history of depression, mental illness, or suicidal thoughts or actions.

You may have unusual thoughts or behavior, or thoughts about suicide, while taking this medicine. Tell your doctor if you have new or worsening depression, or suicidal thoughts. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, trouble sleeping, or if you feel impulsive, or you have thoughts about suicide or hurting yourself. Call your doctor at once if you have rapid and unintended weight loss.

What should I discuss with my healthcare provider before taking roflumilast?

You should not use roflumilast if you are allergic to it, or if you have moderate or severe liver disease.

There are many other drugs that can make roflumilast less effective and should not be used at the same time. This includes:

• 
  

  bosentan (Tracleer);

  
  


• 
  

  dexamethasone (Cortastat, Dexasone, Solurex, DexPak);

  
  


• 
  

  St. John's wort;

  
  


• 
  

  rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);

  
  


• 
  

  a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

  
  


• 
  

  HIV medication such as efavirenz (Sustiva, Atripla), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Norvir, Kaletra);

  
  


• 
  

  medicines to treat narcolepsy, such as armodafanil (Nuvigil) or modafanil (Progivil); or

  
  


• 
  

  seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

  
  

To make sure you can safely take roflumilast, tell your doctor if you have any of these other conditions:

• 
  

  liver disease;

  
  


• 
  

  a history of depression, mental illness, or suicidal thoughts or actions.

  
  

You may have unusual thoughts or behavior, or thoughts about suicide, while taking this medicine. Tell your doctor if you have new or worsening depression, or suicidal thoughts. Your family or other caregivers should also be alert to changes in your mood or symptoms.

FDA pregnancy category C. It is not known whether roflumilast will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Roflumilast can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using roflumilast. Do not give this medication to anyone under 18 years old without medical advice. Do not share this medication with other people, even if they have the same symptoms you have.

How should I take roflumilast?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Roflumilast is usually taken once per day, with or without food. Follow your doctor's instructions.

See also: Roflumilast dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fast or pounding heartbeats, cold or clammy skin, or feeling like you might pass out.

What should I avoid while taking roflumilast?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Roflumilast side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You may have unusual thoughts or behavior, or thoughts about suicide, while taking this medicine. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, trouble sleeping, or if you feel impulsive, or you have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

• 
  

  rapid and unintended weight loss;

  
  


• 
  

  tremors;

  
  


• 
  

  pain or burning when you urinate;

  
  

Less serious side effects may include:

• 
  

  nausea, diarrhea, stomach pain;

  
  


• 
  

  loss of appetite, minor weight loss;

  
  


• 
  

  dizziness;

  
  


• 
  

  runny or stuffy nose;

  
  


• 
  

  back pain; or

  
  


• 
  

  flu symptoms.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Roflumilast Dosing Information

Usual Adult Dose for Chronic Obstructive Pulmonary Disease -- Maintenance:

To reduce the risk of COPD exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations:

500 mcg orally once a day, with or without food.

What other drugs will affect roflumilast?

Tell your doctor about all other medicines you use, especially:

• 
  

  birth control pills;

  
  


• 
  

  cimetidine (Tagamet);

  
  


• 
  

  conivaptan (Vaprisol);

  
  


• 
  

  imatinib (Gleevec);

  
  


• 
  

  isoniazid (for treating tuberculosis);

  
  


• 
  

  lidocaine (Xylocaine);

  
  


• 
  

  methoxsalen (Oxsoralen, Uvadex, 8-Mop);

  
  


• 
  

  primaquine (anti-malaria medication);

  
  


• 
  

  an antidepressant such as fluvoxamine (Luvox) or nefazodone;

  
  


• 
  

  an antibiotic such as ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), norfloxacin (Noroxin), ofloxacin (Floxin), or telithromycin (Ketex);

  
  


• 
  

  antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), o thiabendazole (Mintezol);

  
  


• 
  

  heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), mexiletine (Mexitil), nicardipine (Cardene) or quinidine (Quin-G);

  
  


• 
  

  HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra);

  
  

This list is not complete and other drugs may interact with roflumilast. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More roflumilast resources

• Roflumilast Side Effects (in more detail)
• Roflumilast Dosage
• Roflumilast Use in Pregnancy & Breastfeeding
• Roflumilast Drug Interactions
• Roflumilast Support Group
• 6 Reviews for Roflumilast - Add your own review/rating

• roflumilast Advanced Consumer (Micromedex) - Includes Dosage Information


• Roflumilast Professional Patient Advice (Wolters Kluwer)


• Roflumilast MedFacts Consumer Leaflet (Wolters Kluwer)


• Daliresp Prescribing Information (FDA)


• Daliresp Consumer Overview

Compare roflumilast with other medications

• COPD
• COPD, Maintenance

Where can I get more information?

• Your pharmacist can provide more information about roflumilast.

See also: roflumilast side effects (in more detail)

Oxytetracyclin-Prednisolon-Augensalbe Jenapharm

Oxytetracyclin-Prednisolon-Augensalbe Jenapharm may be available in the countries listed below.

Ingredient matches for Oxytetracyclin-Prednisolon-Augensalbe Jenapharm

Oxytetracycline

Oxytetracycline hydrochloride (a derivative of Oxytetracycline) is reported as an ingredient of Oxytetracyclin-Prednisolon-Augensalbe Jenapharm in the following countries:

• Germany

Prednisolone

Prednisolone is reported as an ingredient of Oxytetracyclin-Prednisolon-Augensalbe Jenapharm in the following countries:

• Germany

International Drug Name Search

Opticlox

Opticlox may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Opticlox

Cloxacillin

Cloxacillin benzathine (a derivative of Cloxacillin) is reported as an ingredient of Opticlox in the following countries:

• Australia


• Netherlands


• United Kingdom

International Drug Name Search

Epaxal

Epaxal

Hepatitis A Vaccine

inactivated, virosome

Read all of this leaflet carefully before this vaccine is given.

• Keep this leaflet. You may need to read it again.


• If you have further questions, please ask your doctor or your pharmacist.

In this leaflet:

• 1. What Epaxal is and what it is used for


• 2. Before having Epaxal


• 3. How Epaxal is given


• 4. Possible side effects


• 5. Storing Epaxal


• 6. Further information

The full name of the vaccine is Epaxal, emulsion for injection in pre-filled syringe, Hepatitis A vaccine (inactivated, virosome)

• The active substance in Epaxal is 24 international units of inactivated (killed) hepatitis A virus (strain RG-SB) that has been grown in human diploid cells. The viruses have been adsorbed on to particles called virosomes that are made from parts of the outer coat of a type of influenza virus and phospholipids called lecithin and cephalin.



• The other ingredients are sodium chloride and water for injections.

The Product License Holder is

Berna Biotech Italia S.r.l.

Via Zambeletti 25

20021 Baranzate (MI)

Italy

Epaxal is manufactured by

Berna Biotech Ltd

Rehhagstrasse 79

3018 Berne

Switzerland

What Epaxal is and what it is used for

Epaxal is provided as a clear, colourless liquid in a pre-filled syringe that contains a single 0.5 ml dose. The vaccine is available in packs of one or 10 pre-filled syringes.

Epaxal is a vaccine which contains killed hepatitis A virus. It works by causing your body to produce antibodies (your body’s natural defence system) against the hepatitis A virus. These antibodies will protect you against hepatitis A infection from about 2 to 4 weeks after the injection. Epaxal can be used in children from 1 year of age and adults.

Some general information about hepatitis A is given at the end of this leaflet.

Epaxal will only protect you against hepatitis A and not against any other type of hepatitis virus or any other illness that can cause hepatitis (inflammation of the liver).

Before having Epaxal

You should not have Epaxal if the answer to any of the following questions is “YES”. If you are unsure of anything or have questions, please talk to your doctor, nurse or pharmacist before the vaccine is given.

• Are you allergic to eggs or to products made from chicken?


• Are you allergic to formaldehyde?


• Are you allergic to any of the ingredients of the vaccine?

Also, vaccination may have to be delayed if the answer to the following question is “YES”:

• Do you have an infection with a fever at the moment?

Take special care with Epaxal

If the answer to the following question is “YES”, please tell your doctor, nurse or pharmacist before the vaccine is administered.

• Do you have a poor immune system (poor resistance to infections)? You may still be able to have Epaxal, but you may not develop enough antibodies after a single injection to protect you against infection. See section 3 about the need
  for an early booster dose.

Also, please note the following:

• Is the person to be vaccinated less than one year old? Epaxal is not recommended below the age of one year.


• Are you more than 60 years old? You can still have Epaxal but information on protection in people over 60 is limited.

Please take note that if you normally have a flu vaccine, you will still need to have it. Although there are small amounts of influenza virus protein in Epaxal, the vaccine will not protect you against catching flu.

Pregnancy and breast-feeding

Epaxal should only be given to pregnant women if it is clearly necessary. If you are or think that you might be pregnant, discuss this with your doctor or nurse before having Epaxal.

It is not known if the vaccine passes into the breast milk. Talk to your doctor or nurse if you are breast-feeding.

Driving and using machines

Having this vaccine occasionally gives people dizziness or headaches that might affect your ability to drive or use machines.

Taking/using other medicines and having other vaccines

Please inform your doctor or nurse if you are taking or have recently taken any other medicines, even those not prescribed.

You can take tablets for the prevention of malaria on the same days as having doses of Epaxal. There is no need to stop the medicine.

Epaxal can be given at the same time as vaccines against yellow fever, typhoid fever, poliomyelitis, diphtheria, tetanus, meningococci A + C and influenza.

Vaccines given at the same time as Epaxal will be given using a separate syringe and at different injection sites.

You can also receive a dose of human gamma globulin (antibody) if it is necessary to protect you immediately against hepataitis A infection. The gammaglobulin should be given at a different injection site.

How Epaxal is given

Your doctor or nurse will inject the vaccine into the muscle, usually in your upper arm. In people who have conditions that make them bleed easily or whose blood does not clot normally, Epaxal can be given just below the skin.

The dose for all ages from one year upwards is 0.5 ml.

Protection against hepatitis A following the first vaccine dose should last for at least one year. To make sure that protection against hepatitis A is continued, a second dose of 0.5 ml should be given. It is best if this is given between 6 and 12 months after the first dose but it is known that a very good immune response to the booster occurs when the second dose is given up to 4 years later. Even if more than 4 years have gone by, you can still have a second dose of Epaxal
to boost your immunity.

People who have poor immunity to infections for any reason, should have a second dose earlier than other people, usually between 1 and 6 months after the first dose.

If you received your first vaccine dose with another hepatitis A vaccine, you can still be given Epaxal for the booster vaccination. Also, people who received Epaxal for the first dose can be boosted with another hepatitis A vaccine if necessary.

Epaxal Side Effects

Like all medicines, Epaxal can have side effects.

Serious allergic reactions are always a possibility after receiving a vaccine.

These reactions (reported by less than 1 in 10,000 people) may include difficulty in breathing, blue discolouration of the tongue or lips, low blood pressure (causing dizziness) and collapse. When these signs or symptoms occur they usually
develop very quickly after the injection is given and while the person affected is still in the clinic or doctor’s surgery. If any of these symptoms occur after leaving the place where your injection was given, you must consult a doctor immediately.

Very common side effects (reported by more than 1 in 10 people) are pain at the injection site, tiredness and headaches.

Common side effects (reported by less than 1 in 10 but more than 1 in a 100 people) are:

• feeling sick


• diarrhoea


• loss of appetite


• redness, swelling or lumpiness at the site of injection


• generally feeling unwell


• fever (high temperature)

Uncommon side effects (reported by less than 1 in a 100 but more than 1 in a 1000 people) are:

• itchiness of the skin


• a rash


• dizziness


• being sick


• joint pain

Very rarely there may be reactions involving the nerves. You should tell your doctor immediately if you notice any of the following: pins and needles, loss of feeling or numbness and problems moving your arms or legs. Also, blood tests that measure how the liver is working sometimes show some slight changes for a brief period after vaccination.

If you notice any other effects after the vaccination that are not mentioned here, tell your doctor, nurse or pharmacist.

Storing Epaxal

Epaxal should be stored at 2–8 °C (in a refrigerator) and protected from light. It must not be frozen. The vaccine must not be used after the expiry date.

Keep Epaxal out of the reach and sight of children.

Further Information

Epaxal is distributed in the UK by:

MASTA

Moorfield Road

Yeadon

Leads

LS19 7BN

This leaflet was last revised in March 2006

Disease information on hepatitis A

Hepatitis A is a liver disease caused by the hepatitis A virus. You can catch the virus by eating or drinking contaminated food or water. The virus is present in the stools of infected people, even if they show no signs of the disease. You can catch hepatitis A infection in any country but the risk is highest in countries where sanitation and food and water hygiene are poor.

After catching the virus, it can be up to six weeks before signs of illness are seen. Some people have the virus and never get ill but they can still infect other people during this time.

The main signs of the illness include a headache, fever, sickness and jaundice (yellowing of the skin and eyes). These signs are all due to an inflammation of the liver while it is infected with the virus. Most patients get better usually after a couple of months, but a few people may take up to a year to make a full recovery. Whilst recovering, people affected with hepatitis A may be unable to work, they may not be able to drink alcohol and may need to avoid certain foods according
to their doctors’ advice. Severe complications are very rare but sometimes the liver stops working and very special hospital care is needed until the infection gets better. The severity of the disease increases with age, and adults above
the age of 40–50 years are at an increased risk to suffer from complications, which can sometimes be fatal.

There are many other types of virus that can cause hepatitis. The signs may be the same as in hepatitis A infection but the other viruses are not always caught through food and drink. Epaxal can help to protect you against infection with
the hepatitis A virus only.

Berna Biotech Ltd

Berne

Switzerland

900622gb1pr.004

Gabapentina Combix

Gabapentina Combix may be available in the countries listed below.

Ingredient matches for Gabapentina Combix

Gabapentin

Gabapentin is reported as an ingredient of Gabapentina Combix in the following countries:

• Spain

International Drug Name Search

Triple Wormer

Dosage Form: FOR ANIMAL USE ONLY
TripleWormer™

(pyrantel pamoate/praziquantel)

FOR PUPPIES AND SMALL DOGS

Durvet Triple Wormer™ Flavored Chewables

Package contents: Blisters of 2 or 12 chewables

DRUG FACTS

Active Ingredients (in each chewable)

Pyrantel Pamoate (30mg) and Praziquantel (30mg)

Purpose

De-wormer for Small Dogs and Puppies Only (6.0 to 25 pounds)

Uses

For the treatment and control of

• Roundworms (Toxocara canis, Toxascaris leonina)


• Hookworms (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala)


• Tapeworms (Dipylidium caninum, Taenia pisiformis)

Human Warning

Keep this and all medication out of the reach of children. To obtain product information, including a Material Safety Data Sheet (MSDS), call 1-800-821-5570.

When Using This Product:

• Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.


• Do not de-worm a dog or puppy that is sick. Consult a veterinarian for diagnosis of the illness.


• Durvet Triple Wormer™ Flavored Chewables are safe for use in puppies12 weeks or older and adult dogs. Safety in breeding dogs and pregnant bitches has not been tested.

You May Notice

Vomiting, loose stools (with or without blood) and decreased activity following treatment. If you notice these signs, contact a veterinarian.

Directions

Each flavored chewable contains 30 mg of pyrantel pamoate and 30 mg of praziquantel. The dose for each drug is 2.27 mg per pound of body weight (5 mg/kg). Please refer to the following dosing table for help finding the right dose for your dog.

Durvet Triple Wormer™ Flavored Chewables Dosing Table

Dog Weight	Number of Chewables
6.0 to 12.0 pounds	1
12.1 to 25 pounds	2
More than 25 pounds	Use the 114 mg size

• You should weigh your dog to make sure you are giving the right dose.


• Durvet Triple Wormer™ Flavored Chewables are palatable if offered by hand. If your dog does not voluntarily eat the chewable, you can hide the chewable in a small amount of food or place it in the back of the dog's mouth for forced swallowing.


• Make sure that the dog eats the complete dose.


• Watch the dog for a few minutes after dosing to make sure the chewable is not rejected.

OTHER INFORMATION

Recommended De-Worming Schedule

Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. De-worming schedules may vary depending on the climate where you live and the activity of your dog.

Re-treatment

Re-treatment of your dog may be necessary as determined by laboratory fecal examination and/or if your dog is living where re-infections are likely to occur. Consult your veterinarian for assistance in the diagnosis and prevention of re-infection. In case of re-infection with tapeworms (Dipylidium caninum), consult your veterinarian for advice on how to remove fleas from the dog and the environment.

Storage

Store at controlled room temperature of 59-86°F (15-30°C).

Questions? Comments?

To report a suspected adverse reaction, call 1-800-821-5570

If you have questions or comments about this product, please write: Durvet, Inc., PO Box 279, Blue Springs, MO 64013

Manufactured for:

Durvet, Inc., 100 S.E. Magellan Drive, Blue Springs, MO 64014

MADE IN USA

NADA141-261, Approved by FDA ACAV P002632-1 06/07

PRINCIPAL DISPLAY PANEL - 30 mg Tablet Carton

NDC 30798-185-61

FOR PUPPIES AND SMALL DOGS

TripleWormer™

(pyrantel pamoate/praziquantel)

2

tablets

CHEWABLE FLAVORED DOG DE-WORMER TABLETS

Broad Spectrum

De-Wormer

For Puppies & Small Dogs

6 lbs. to 25 lbs.

For the treatment and control of:

roundworms (Toxocara canis, Toxascaris leonina);

hookworms (Ancylostoma caninum, Ancylostoma

braziliense, Uncinaria stenocephala);

tapeworms (Dipylidium caninum,Taenia

pisiformis) in dogs and puppies.

Active ingredient: Each flavored chewable contains

30 mg pyrantel pamoate and 30 mg praziquantel.

KEEP OUT OF REACH OF CHILDREN

FOR USE ONLY AS DIRECTED ON PACKAGE INSERT & BACK PANEL

NET CONTENTS: 2 FLAVORED TABLETS

NADA #141-261, APPROVED BY FDA

durvet

Triple Wormer  pyrantel pamoate and praziquantel  tablet, chewable

Product Information Product Type OTC ANIMAL DRUG NDC Product Code (Source) 30798-185 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength pyrantel pamoate (pyrantel) pyrantel pamoate 30 mg praziquantel (praziquantel) praziquantel 30 mg

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color BROWN Score 2 pieces Shape ROUND Size 10mm Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 30798-185-61 2 TABLET In 1 BOX, UNIT-DOSE None 2 30798-185-71 12 TABLET In 1 BOX, UNIT-DOSE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NADA	NADA141261	03/06/2010

Labeler - Durvet, Inc. (056387798)

Registrant - Virbac AH, Inc. (131568396)

Establishment
Name	Address	ID/FEI	Operations
Virbac Bridgeton		808558100	MANUFACTURE

Revised: 03/2010Durvet, Inc.