Pen-V Lannacher may be available in the countries listed below.
Phenoxymethylpenicillin potassium (a derivative of Phenoxymethylpenicillin) is reported as an ingredient of Pen-V Lannacher in the following countries:
International Drug Name Search
Generic Name: chlorpheniramine and pseudoephedrine (klor fen EER a meen and soo doe e FED rin)
Brand Names: AccuHist Drops, Allerest Maximum Strength, Brexin L.A., Colfed-A, D-Amine-SR, Dayquil Allergy, Deconamine, Dicel, Dicel Chewables, Dura-Tap/PD, Durafed, Duratuss DA, Dynahist-ER Pediatric, Genaphed Plus, Histade, Histex, Kronofed-A, Kronofed-A-Jr, LoHist-D, Mintex, Neutrahist Drops, Re2+30, Rescon-Ed, Suclor, SudaHist, Sudal-12 Chewable, Sudal-12 Tannate, Sudogest Cold & Allergy, SudoGest Sinus & Allergy, Tavist-DA, Triaminic Cold and Allergy, Triaminic Softchew Cold and Allergy, Triaminic Softchews Allergy Runny Nose and Congestion
Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
The combination of chlorpheniramine and pseudoephedrine is used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.
Chlorpheniramine and pseudoephedrine may also be used for other purposes not listed in this medication guide.
There are many brands and forms of this medication available and not all brands are listed on this leaflet.
Do not use this medication during an asthma attack.
Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.
severe or uncontrolled high blood pressure;
severe coronary artery disease;
narrow angle glaucoma;
a stomach ulcer;
if you are unable to urinate; or
if you are having an asthma attack.
Ask a doctor or pharmacist if it is safe for you to take this medication if you have:
diabetes;
glaucoma;
circulation problems;
heart disease or high blood pressure;
overactive thyroid;
a seizure disorder such as epilepsy;
asthma, emphysema or chronic bronchitis; or
urination problems or an enlarged prostate.
Artificially sweetened liquid cold medicine may contain phenylalanine. If you have phenylketonuria (PKU), check the medication label to see if the product contains phenylalanine.
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.
The chewable tablet must be chewed before swallowing.
Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.
This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.
If you need surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.
Since cold medicine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include some of the serious side effects listed in this medication guide.
Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.
fast or pounding heartbeats;
confusion, hallucinations, unusual thoughts or behavior;
severe dizziness, anxiety, restless feeling, nervousness;
urinating less than usual or not at all;
easy bruising or bleeding, unusual weakness; or
seizure (black-out or convulsions).
Less serious side effects may include:
blurred vision;
dry nose or mouth;
nausea, stomach pain, constipation, loss of appetite;
dizziness, drowsiness;
problems with memory or concentration;
ringing in your ears; or
feeling restless or excited (especially in children).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 800 FDA 1088.
Tell your doctor about all other medications you use, especially:
mecamylamine (Inversine);
methyldopa (Aldomet);
reserpine;
a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;
a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or
an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), nortriptyline (Pamelor), and others.
This list is not complete and other drugs may interact with chlorpheniramine and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
See also: Histade side effects (in more detail)
Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Fluoxetine outweigh the risks.
Family and caregivers must closely watch patients who take Fluoxetine. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.
Treating premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome. It may also be used for other conditions as determined by your doctor.
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI). It works by restoring the balance of serotonin, a natural substance in the brain, which helps to improve mood.
Contact your doctor or health care provider right away if any of these apply to you.
Treatments for depression are getting better everyday and there are things you can start doing right away.
Some medical conditions may interact with Fluoxetine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Fluoxetine. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Fluoxetine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Fluoxetine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Fluoxetine.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Anxiety; decreased sexual desire or ability; diarrhea; dizziness; drowsiness; dry mouth; flu-like symptoms (eg, fever, chills, muscle aches); increased sweating; loss of appetite; nausea; nervousness; runny nose; sore throat; stomach upset; trouble sleeping; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bizarre behavior; black or bloody stools; chest pain; confusion; decreased concentration; decreased coordination; exaggerated reflexes; excessive sweating; fainting; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; increased hunger, thirst, or urination; joint or wrist aches or pain; memory loss; new or worsening agitation, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, or inability to sit still; persistent or severe ringing in the ears; persistent, painful erection; red, swollen, blistered, or peeling skin; seizures; severe or persistent anxiety, trouble sleeping, or weakness; severe or persistent nausea, vomiting, diarrhea, or headache; significant weight loss; stomach pain; suicidal thoughts or attempts; tremor; trouble urinating; unusual bruising or bleeding; unusual hoarseness; unusual or severe mental or mood changes; unusual swelling; unusual weakness; vision changes; worsening of depression.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Fluoxetine side effects (in more detail)
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include coma; confusion; delirium; difficult breathing; fainting; fast, slow, or irregular heartbeat; fever; seizures; severe or persistent dizziness, drowsiness, nausea, or vomiting; tremor.
Store Fluoxetine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fluoxetine out of the reach of children and away from pets.
This information is summary only. It does not contain all information about Fluoxetine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Generic Name: naproxen (Oral route)
na-PROX-en
NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Naproxen is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .
In the U.S.
In Canada
Available Dosage Forms:
Therapeutic Class: Analgesic
Pharmacologic Class: NSAID
Chemical Class: Propionic Acid (class)
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis) such as inflammation, swelling, stiffness, and joint pain. Naproxen also helps relieve symptoms of ankylosing spondylitis, which is a type of arthritis that affects the joints in the spine. However, this medicine does not cure arthritis and will help you only as long as you continue to take it.
This medicine may also be used to treat mild to moderate pain, including acute gout and other painful conditions such as bursitis, tendonitis, or menstrual cramps.
This medicine is available only with your doctor's prescription.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of naproxen controlled-release tablets in the pediatric population. Safety and efficacy have not been established.
Appropriate studies have not been performed on the relationship of age to the effects of naproxen delayed release tablets, suspension, and tablets in children younger than 2 years of age. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of naproxen in the elderly. However, elderly patients may be more sensitive to the effects of naproxen than younger adults, and are more likely to have age-related kidney or stomach problems, which may require caution and an adjustment in the dose for patients receiving naproxen.
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
This section provides information on the proper use of a number of products that contain naproxen. It may not be specific to Naxen. Please read with care.
For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients.
This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.
When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine.
Check with your doctor first before changing dosage forms (e.g., tablets, suspension). These forms are very different from each other.
Swallow the delayed-release tablet whole. Do not crush, break, or chew it.
If you are using the suspension, shake it gently before using it. Use the marked measuring cup included in the package to measure the dose.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects.
This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk.
This medicine may cause bleeding in your stomach or intestines. This problem can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years of age, are in poor health, or are using certain other medicines (such as a steroid or a blood thinner).
Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, or loosening of the skin; chills; cough; diarrhea; fever; itching; joint or muscle pain; red skin lesions; sore throat; sores, ulcers, or white spots in the mouth or on the lips; or unusual tiredness or weakness.
Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, or lower legs; severe stomach pain, black, tarry stools, or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; unusual bleeding or bruising; or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in the chest, fast or irregular heartbeat, unusual flushing or warmth of the skin, weakness, or slurring of speech. Stop taking this medicine and check with your doctor immediately if you notice any of these warning signs.
This medicine may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal anti-inflammatory drugs. Anaphylaxis can be life-threatening and requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once.
Using this medicine during late pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.
Check with your doctor immediately if blurred vision, difficulty with reading, or any other change in vision occurs during or after your treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
Before having any kind of surgery or medical tests, tell your doctor that you are taking this medicine. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure.
This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert. .
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Get emergency help immediately if any of the following symptoms of overdose occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Naxen side effects (in more detail)
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Class: Central Nervous System Agents, Miscellaneous
VA Class: CN900
Chemical Name: 6-(Trifluoromethoxy)-2-benzothiazolamine
Molecular Formula: C8H5F3N2OS
CAS Number: 1744-22-5
Brands: Rilutek
An antiglutamate agent that acts in the CNS;1 2 3 4 5 6 7 10 11 12 13 a synthetic aryl-substituted benzothiazolamine.1 2 3 4 5 6 7 8 9
Used in the management of amyotrophic lateral sclerosis (ALS, Lou Gehrig disease, Dejerine-type Charcot syndrome) to extend survival and/or time to tracheostomy;1 7 8 11 15 22 24 designated an orphan drug by FDA for this use.26
Measure serum aminotransferases, including ALT levels, before and during riluzole therapy.8 (See Hepatic Effects under Cautions.)
Administer orally, usually in 2 equally divided doses daily, 1 hour before or 2 hours after meals.1 8 22 24 (See Food under Pharmacokinetics.)
50 mg every 12 hours.8
Maximum 50 mg every 12 hours; higher daily dosages provide no additional benefit but may increase the risk of adverse effects.8 22 24
Use with caution; however, no specific dosage recommendations.a
Discontinue therapy if ALT is >10 times ULN or if jaundice develops.a
Manufacturer states that there is no experience with reinitiating therapy in patients whose therapy was discontinued for ALT >5 times ULN.a
Use with caution; however, no specific dosage recommendations.a
Use with caution; however, no specific dosage recommendations.a
History of severe hypersensitivity reactions to riluzole or any ingredient in the formulation.8
Associated with increases in serum aminotransferase (ALT) concentrations.a Maximum increases usually occur within 3 months of initiating therapy and are usually transient when <5 times ULN.8
Rarely, jaundice has been reported.a
Use not recommended in patients with baseline elevations of liver function tests (especially increased bilirubin).a Use with caution in patients with current or a history of abnormal liver function (i.e., significant abnormalities in serum transaminase [ALT; AST], bilirubin, and/or gamma-glutamate transferase [GGT] levels).a
Determine serum aminotransferase (ALT) concentrations prior to initiating therapy, once monthly during the first 3 months, every 3 months during the first year, and periodically thereafter; determine more frequently if increases in ALT concentrations develop.a
Manufacturer states there is no experience of continuing treatment in patients whose ALT is >5 times ULN and if a decision is made to continue therapy, at least weekly monitoring of liver function tests is recommended.a
Neutropenia (ANC <500/mm3) reported rarely within the first 2 months of therapy.8 Monitor WBC counts if febrile illness occurs.8
Category C. 8
Distributed into milk in rats; not known whether distributed into human milk.a Discontinue nursing because of potential risk to nursing infants.8
Safety and efficacy not established in children <18 years of age.8 22
Possible increased incidence of hepatic dysfunction compared with younger adults.8 Use with caution due to greater frequency of decreased hepatic and/or renal function observed in the elderly.8 Adverse effects similar to those in younger adults.8
Use with caution;8 increased AUC in patients with mild or moderate hepatic impairment.8 Pharmacokinetics not studied in patients with severe hepatic impairment.8
Manufacturer states there is no experience with continuing treatment in patients once ALT >5 times ULN and if a decision is made to continue therapy, frequent monitoring (at least weekly) of liver function tests is recommended.a
Use with caution.8 There is no significant difference in pharmacokinetic parameters between patients with moderate or severe renal insufficiency and healthy volunteers. 8 Pharmacokinetics not studied in patients undergoing hemodialysis.8
Asthenia, nausea, dizziness, decreased lung function, diarrhea, abdominal pain, pneumonia, vomiting, vertigo, circumoral paresthesia, anorexia, somnolence.8
Appears to be metabolized principally by CYP1A2; pharmacokinetic interactions with substrates of CYP1A2 are likely.8 CYP2D6, 2C19, 3A4, and 2E1 not significantly involved in metabolism.a
Not known whether riluzole has potential for enzyme induction in humans.8
Potential pharmacokinetic interactions (displacement of riluzole or other protein-bound drugs).8
Inhibitors of CYP1A2: potential pharmacokinetic interaction (decreased rate of riluzole elimination).8
Inducers of CYP1A2: potential pharmacokinetic interaction (increased rate of riluzole elimination).8
Drug | Interaction | Comments |
|---|---|---|
Alcohol | Possible additive adverse hepatic effects8 | |
Allopurinol | Possible additive adverse hepatic effects8 | Safety of concomitant administration not established; use caution8 |
Amitriptyline | Possible decreased rate of riluzole eliminationa | |
Caffeine | Possible decreased rate of riluzole eliminationa | |
Charcoal-broiled food | Possible increased rate of riluzole eliminationa | |
Cigarette smoke | Possible increased rate of riluzole eliminationa | |
Digoxin | No effect on riluzole protein binding in vitroa | |
Imipramine | No effect on riluzole protein binding in vitroa | |
Methyldopa | Possible additive adverse hepatic effects8 | Safety of concomitant administration not established; use caution8 |
Omeprazole | Possible increased rate of riluzole elimination | |
Phenacetin | Possible decreased rate of riluzole elimination | |
Quinine | No effect on riluzole protein binding in vitroa | |
Quinolones | Possible decreased rate of riluzole eliminationa | |
Rifampin | Possible increased rate of riluzole elimination | |
Sulfasalazine | Possible additive adverse hepatic effects8 | Safety of concomitant administration not established; use caution8 |
Tacrine | Potential pharmacokinetic interaction (altered metabolism) with concurrent use of other drugs metabolized by CYP1A2a | |
Theophylline | Possible decreased rate of riluzole elimination | |
Warfarin | No effect on riluzole or warfarin protein binding in vitroa |
Well-absorbed (approximately 90%); average absolute oral bioavailability approximately 60%.8
With multiple-dose administration, riluzole accumulates in plasma by about twofold; steady-state is reached in <5 days.8
High fat meal decreases absorption, reducing AUC by about 20% and peak blood levels by about 45%.8
Increased AUC in patients with mild or moderate hepatic impairment.8 Pharmacokinetics not studied in patients with severe hepatic impairment.8
96% (mainly to albumin and lipoproteins).8
Extensively metabolized in the liver to 6 major and a number of minor metabolites, principally via CYP1A2-dependent hydroxylation and glucuronidation.
Excreted in urine (90%) mainly as metabolites and in feces (5%).8
Averages 12 hours after repeated doses.8
20°–25°C; protect from bright light.8
Precise mechanism of action has not been fully elucidated but appears to involve interference with the effects mediated by excitatory amino acids (EAAs) in the CNS, possibly through inhibition of glutamic acid release,1 2 3 4 5 6 8 9 11 12 15 17 18 blockade or inactivation of voltage-dependent sodium channels,1 4 5 6 7 8 15 17 18 19 and/or activation of a G-protein-dependent signal transduction pathway.1 6 17
May act via noncompetitive blockade of EAA receptors;5 14 however, does not appear to bind to any known glutamate receptor.2 4 6
Exhibits neuroprotective properties in vitro and in vivo in animals, including inhibition of neuronal toxicity associated with exposure to EAAs 7 8 or cerebrospinal fluid from ALS patients,6 7 and inhibits neuronal toxicity associated with anoxia4 7 8 9 or focal or global ischemia.2 3 4 6 7 9
Prolonged survival in a study in a transgenic mouse model of ALS but did not delay onset of the disease.8 21 22
Importance of patients informing clinician of any febrile illness.8
Importance of taking riluzole on a regular basis and at the same time of the day (e.g., in the morning and evening) each day.8 Importance of taking every 12 hours on an empty stomach, 1 hour before or 2 hours after meals.1 8 22 24
If a dose is missed, importance of patient taking only the next scheduled dose.8
Risk of dizziness, vertigo, or somnolence: avoid driving or operating machinery until effects on individual are known.8
Alcohol may increase the risk of serious hepatotoxicity; drinking excessive amounts of alcohol should be discouraged.8
Importance of keeping riluzole out of the reach of children.8
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.8
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.8
Importance of informing patients of other important precautionary information. (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Oral | Tablets, film-coated | 50 mg | Rilutek | Aventis |
This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.
Rilutek 50MG Tablets (SANOFI-AVENTIS U.S.): 60/$999.99 or 180/$2950.97
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions May 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
1. Bensimon G, Lacomblez L, Meininger V et al. A controlled trial of riluzole in amyotrophic lateral sclerosis. N Engl J Med. 1994; 330:585-91. [IDIS 326262] [PubMed 8302340]
2. Mantz J, Chéramy A, Thierry AM et al. Anesthetic properties of riluzole (54274 RP), a new inhibitor of glutamate neurotransmission. Anesthesiology. 1992; 76:844-8. [PubMed 1349464]
3. Mantz J, Laudenbach V, Lecharny JB et al. Riluzole, a novel antiglutamate, blocks GABA uptake by striatal synaptosomes. Eur J Pharmacol. 1994; 257:R7-8. [PubMed 8082687]
4. Martin D, Thompson MA, Nadler JV. The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur J Pharmacol. 1993; 250:473-6. [PubMed 8112408]
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Alfa-Amylase Biogaran may be available in the countries listed below.
Amylase, Alpha- is reported as an ingredient of Alfa-Amylase Biogaran in the following countries:
International Drug Name Search
Generic Name: brentuximab (Intravenous route)
bren-TUX-i-mab ve-DOE-tin
Progressive multifocal leukoencephalopathy and/or death may occur, as a result of JC virus infection, in patients receiving brentuximab therapy .
In the U.S.
Available Dosage Forms:
Pharmacologic Class: Mitotic Inhibitor
Brentuximab injection is used to treat a type of cancer called Hodgkin's lymphoma (HL). It is given to patients who have received an autologous stem cell transplant (ASCT) or other cancer treatments that did not work well.
Brentuximab injection is also used to treat patients with systemic anaplastic large cell lymphoma (sALCL). It is used after at least one other cancer medicine was given and did not work well.
Brentuximab interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by brentuximab, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, such as a skin rash, may not be serious but may cause concern. Some effects do not occur until months or years after the medicine is used.
This medicine is to be administered only by or under the immediate supervision of your doctor.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of brentuximab injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies have not been performed on the relationship of age to the effects of brentuximab injection in the geriatric population. Safety and efficacy have not been established.
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | D | Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. |
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.
This medicine must be given slowly, so the needle will remain in place for 30 minutes. It is usually given every 3 weeks until your condition improves. You may also receive medicines (e.g., acetaminophen, steroid medicines) to help prevent possible allergic reactions to the injection.
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.
Do not take this medicine together with bleomycin (Blenoxane®). Using these medicines together may cause serious side effects, such as cough, shortness of breath, troubled breathing, or wheezing
Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.
This medicine may cause a serious side effect called an infusion reaction. This can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a fever, chills, trouble with breathing, lightheadedness, fainting, or chest pain within a few hours after you receive it.
This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are receiving this medicine.
Check with your doctor if you notice any signs of fever, chills, sore throat, or painful urination. These could be symptoms of an infection resulting from low white blood cell counts.
This medicine may cause a serious type of reaction called tumor lysis syndrome (TLS). Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount; joint pain, stiffness, or swelling; lower back, side, or stomach pain; a rapid weight gain; swelling of the feet or lower legs; or unusual tiredness or weakness.
Serious skin reactions can occur during treatment with this medicine. Stop using this medicine and check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using this medicine.
This medicine may cause a rare and serious brain infection called progressive multifocal leukoencephalopathy (PML). Talk to your doctor about the benefits of using this medicine and the risk of this infection. Check with your doctor right away if you are having more than one of these symptoms: vision changes, loss of coordination, clumsiness, memory loss, difficulty speaking or understanding what others say, and weakness in the legs.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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